Proteins at Ice/Water Interfaces

image017Description: Antifreeze Proteins (AFPs) found in fish, plants and insects help the organisms to survive cold temperatures. Various applications of such molecules are in agricultural (grain preservation and transgenic plants), medicine (organ preservation and cryosurgery), aerospace (wing de-icers) and other industries.

Goals: The goal of this project is to apply various computational techniques such as MM, MD and QSAR to elucidate the molecular mechanism of these proteins. As an outcome of this research a more potent antifreeze molecule will be proposed for industrial use.


  • Dalal, P., et al., Hydrogen bond analysis of type 1 antifreeze protein in water and the ice/water interface. PhysChemComm,: Paper No. 7. 2001
  • Dalal, P., et al., “Antifreeze” Proteins at the Ice/Water Interface: Three calculated discriminating properties for orientation of Type I proteins. Manuscript in Preparation, 2004.