Oligosaccharide – Protein Interactions

image007Description: A multi-disciplinary research project that is exploring sugar – protein interactions and is developing fundamental scientific discoveries and advances leading to a new understanding of biochemistry. This project is a collaborative project between a biochemistry group at the University of South Alabama and here. The computational component being undertaken at Duquesne along with some basic physical characterization experiments.

Goals: The proposed goals of this project are to elucidate the important interactions between oligosaccharides and proteins. This is currently being accomplished using computational methods, such as free energy simulations and docking techniques. Additionally these computations are being supported by isothermal titration calorimetry and fluorescence experiments. This research is trying to understand the role of these proteins has in breast cancer.


  • Aronson, N. N. Jr. et al. Homology Modeling of Glycosyl Hydrolase Family 18 Enzymes and Proteins. Journal of Chemical Information and Computer Sciences. 37(6), 999-1005. 1997.
  • Dalal, P et al. Molecular Dynamics Simulations of Oligosaccharide-Protein Interactions. Manuscript in preparation, 2004