Conformational Change and Transport of the Monoamine Transporters


ebenner2Depleted neurotransmitter concentration in the synaptic cleft can lead to a variety of psychological diseases, notably depression, anxiety, and addiction. Neurotransmitter sodium symporter proteins are responsible for reuptake of neurotransmitters to the presynaptic neuron. Understanding transport mechanisms and conformations of these proteins can help in the development of drugs to combat these diseases. Our work focuses on the computational modeling of the dopamine and serotonin transporters using a dual bilayer system with emphasis on the reset of transport. We are studying the role of potassium plays in this mechanism and performing detailed conformational analysis.

 Marco J. Acevedo, Undergraduate Student
 Emily Benner, Graduate Student