Computational Study of the Serotonin Transporter (SERT) and other Central Nervous System (CNS) Targets

mike-projectAn area of interest in the lab is CNS disorders such as depression. One of the primary targets of treating depression is the serotonin transporter, which is responsible for the reuptake of serotonin into the cell from the synaptic cleft. There are no known crystal structures for this protein at this moment. The lab’s focus is modeling SERT to utilize in fragment based drug design strategies with the intent of developing and pharmacologically validating potential leads.

Michael J. Wasko, Graduate Student